Ingredients :     Fraxinus excelsior

Active Ingredients: Glucoside, coumarin, secoiridoids phenyl ethanoids, flavonoids, oleanolic acid, betulin, betulinic acid,  β-amirin, sterols, Sitosterol , Coumarins , Phenylethanoids

sitosterol, coumarins, phenylethanoids.

 Indications: Boost sexual power  , increase the power of erection , enhance sexual potency , increase sperm count and increase fertility

Dosage and administration: Drink the contents of one-third of the sachet  in some water every 8 hours.

Side effects: In case of overdose  In severely hot-tempered people (acute biliary disorders) may cause headaches. In case of headache, we recommend the patient to eat coriander vegetables during the day.

Recommended tips : does not have

Pharmacological  effects and mechanism of  action MOA: Men's impotence can be caused by androgen deficiency, and in older men, atherosclerosis, diabetes mellitus, spinal cord injury, high cholesterol, high blood pressure, prostate surgery, prostate and heart disease, anatomical abnormalities of the penis, social and psychological conditions as a relationship Dissatisfied marriage, depression and stress. Sexual dysfunction, characterized in part by a decrease in nitric oxide (NO) production.

Penile erection occurs in response to cavernous smooth muscle relaxation, increased blood flow to the penis, and restriction of venous outflow. These events are regulated by a spinal reflex relying on visual, imaginative, and olfactory stimuli generated within the central nervous system (CNS) and on tactile stimuli to the penis. Drugs can have a facilitatory or inhibitory effect either on the nerves regulating this reflex or on the cavernous smooth muscle. A balance between contractile and relaxant factors governs flaccidity/rigidity within the penis. Drugs that raise cytosolic calcium either prevent or abort erection. Conversely, drugs that lower cytosolic calcium relax smooth muscle and can initiate penile erection. (Glutamate as the abundant mammalian neurotransmitter and excessive extracellular level of glutamate cause the activation of glucose receptors and overloading of neuronal calcium (Ca+2) level that leads to glutamate induced neuronal injury . Oleuropein isolated from Fraxinus rhynchophylla can be used as neuroprotective agents against colchicine)Efficacy in treating

erectile dysfunction (ED) with phosphodiesterase inhibitors, especially type 5;

α-adrenergic-receptor antagonists; and dopamine agonists exploit these

mechanisms within the penis or CNS. Penile erection also occurs through inhibition

 of contractile mechanisms. Contraction of cavernous smooth muscle by NE is the

result of activation of α1-adrenergic receptors Based on receptor protein levels ,

the penis contains α1A-, α1B-, and α2A-adrenergic receptors in blood

vessels and smooth muscle. NE released from sympathetic fibers coursing

within cavernous nerves and the dorsal nerve of the penis inhibits erection

of this product from the perspective of traditional medicine:

This product has a unique nature and vascular opening power, strengthens sexual powers, stimulates blood flow, is unique in strengthening sexual power. Healthy and light, it confirms bile in the way of providing "strength".

References:

1-Pmc/Pharmacologic Treatment of Erectile Dysfunction/2002

2-PMC/ Fraxinus: A Plant with Versatile Pharmacological and Biological Activities

3-Researchgate/Aphrodisiac Herbal therapy for Erectile Dysfunction/2020

4-Researchgate/Chemical components of Fraxinus species/2007