Ingredients: Heracleum persicum , Sesamum indicum  , Beeswax

 Active Ingredients: Furanocoumarins‎, Palmitic acid, terpene, Eugenol, cineole, cineole, Palmitic acid, Stearic acid, Linoleic acid, lignans (sesamin, asarinin, sesamolin and sesamol), Prostaglandins and leukotrienes 

Indications: Anti-inflammatory due to rotten humours and various types of wounds and sciatica (anti-discopathy)     

Dosage and administration: Depending on the size of the local, apply a small amount of ointment & keep the sore spot warm.

Side effects:No specific side effects have been reported.

Recommended tips: It is best to massage the desired limb twice a day for 20 minutes each time using a hair dryer and oil, then keep the position completely warm with a cloth. The duration of the treatment until the desired result is obtained.

Contraindications and precautions: Pregnancy

Pharmacological effects and mechanism of action MOA: Rheumatological diseases such as osteoarthritis, rheumatoid arthritis, low back pain, fibromyalgia (the main feature of fibromyalgia is pain spread in soft tissue, which is usually expressed with phrases such as burning, itching, etc. Pain may be in the neck, back, chest, arms, etc. In addition, patients may complain of morning sickness, fatigue, sleep disturbances, or headaches. Common comorbidities include irritable bowel syndrome, chronic fatigue syndrome, depression and anxiety, chronic headaches, multiple drug allergies, and premenstrual syndrome. ) Are very common and the artificial drugs available in the treatment of these diseases have low efficacy and significant adverse effects. While medicinal plants, due to the presence of effective natural substances and the combination of these active ingredients with other substances, create a biological balance and prevent the accumulation of drugs in the body and prevent side effects. The fruits of H.persicum have been functionally used as a traditional drug as a pain killer. Based on well known involvement of free radicals ininflammatory processes, it seems that at least a part of anti-inflammatory effects ofthe essential oil and hydroalcoholic extract of H. persicum fruits may be attributed to their antioxidant constituent sespecially furanocoumarins. Hydroalcoholic extract of H.persicum contains a furanocoumarin named Sphondinwhich has shown inhibitory effect on IL-1 beta-inducedcyclooxygenase-2 expression .Sincethis enzyme has a key role in pain and inflammation, itmay explain the observed effects of Some terpene compounds such as eugenol, cineol andlinalool have anaesthetic, muscle relaxant and inhibitory Our results showed that application of topical sesame oil is effective to reduce pain severity and decrease the frequency of received NSAIDs It is known that sesame oil has a high content of unsaturated fatty acids (palmitic, stearic, oleic and linoleic acids), lignans  (sesamin, asarinin, sesamolin and sesamol) and gamma-tocopherol responsible for pain relief Several studies indicated that fatty acids reduce  the levels of prostaglandins and leukotrienes and thus decrease the pain Palmitic acid .In addition, lignans such as sesamin have been described to relieve  pain .  Omega-6 fatty acids play a similar role to omega-3s in normal growth and reduce joint pain, rheumatoid arthritis and osteoarthritis. These fatty acids  in the body reduce the inflammatory response, which reduces pain

Pharmacological effect of this product from the perspective of traditional medicine: In the third technique of the four techniques of Islamic medicine, which examines the diseases of the organs of the body, under the pain of the external organs of the body, diseases such as back pain, joint pain, joint pain, sciatica. In the etiology of such pain, Regardless of the anatomical causes (abnormalities, deformities, tears, dysplasia) and environmental (excessive fatigue, excessive sexual intercourse, etc.) and underlying disease (disorders of the urinary, genital, respiratory system); Bad temperament and rotten sputum are responsible for the organization of the disease. Cold sputum and the accumulation of raw phlegm sputum, back pain and nausea are common, but the cause of joint pain, sciatica, respectively, priority; Mucus with bile, raw phlegm, bloody sputum, biliary sputum, and rarely soda. If the raw sputum accumulates in the body and the nature of the body does not clear it or is not cleaned by the medicine and the sputum enters the joints, joint pain is inevitable. In this case, the urine will be dilute and the sputum will cause joint pain, mostly waste products and useless in the second and third digestion. Treatment in traditional medicine, depending on the cause, includes: topical, oral, more with a cleansing aspect, such as the use of laxatives, with the razor blade of some vessels (Venesection)

 References: 1-Pmc/The Effects of Topical Sesame (Sesamum indicum) Oil on Pain Severity and Amount of Received Non-Steroid Anti-Inflammatory Drugs in Patients With Upper or Lower Extremities Trauma/2015 2-Researchgate/ Chemistry, pharmacology and medicinal properties of Heracleum persicum Desf. Ex Fischer: A review/2015