Ingredients: Matthiola incana، sesamum indicum، Beeswax.

 Active Ingredients: 11  types  of cardenolides   (such   as   strophanthidin,   bipindogenin,   uzarigenin,   cannogenol   and   digitoxygenin derivatives),  two  flavonoids,  a  cyanidin  and  two  glucosinolates ،cardiac   glycoside.

Indications: For fissures of fingers and anus ( effective for any kind of cracks and fissures in any part of the body)

Dosage and administration: Wash the fissure well every night, lubricate the anal surface with some ointment and the inside.

Side effects: No side effects have been reported

Recommended tips: In case of any problems, consult your doctor. Observe hygiene issues when using the ointment (when lubricating).

Contraindications and precautions: does not have

Pharmacological effects and mechanism of action MOA: Anal fissure is a painful ischemic ulcer that occurs in the lining of the anus. The most common clinical signs are anal pain and bleeding, especially during defecation spasms. The pain may be short-lived or may last for hours. Nightshade contains cardiac steroids, isothiocyanates and flavonoids that have the potential to be used to treat anal fissures. Topical indications for low-dose cardiotonic steroids can have stimulatory effects on the Na + / K + ATPase pump, accelerating wound healing and eliminating tissue ischemia. Cardiac glycosides, which have anti-inflammatory properties, are also considered. Evening primrose isothiocyanates can have protective effects on tissues, and their flavonoids have analgesic, anti-inflammatory and wound healing properties.

Pharmacological effect of this product from the perspective of traditional medicine: Due to its special position, inverted passage and being very sensitive, the anus should be careful about its disability and injury and all its diseases (hemorrhoids, anal swelling, anal fissure, anal loosening, anal protrusion, anal fissure , Anal itching) had the necessary knowledge and prompt treatment. Causes of anal fissures include; Dryness and heat of the anus that dries the bras and subsequently cleaves the anus, Sometimes hot swelling in the anus causes it to rupture, high concentration and dry stools cause cracking, sometimes hemorrhoids cause cleft palate, sometimes the severity of the blood has made it vulnerable to the opening of the anal arteries. In any case, its treatment, depending on the cause of the disease, includes: 1- Crack-inducing drugs (mazo, golnar, stone carcass, Wallflower) Apricot kernel and kernel Peach kernel and walnut oil and bone marrow of beef pen, domestic chicken tallow, camel and sheep hump tail, 3) Remedy for inflammation (ace oil, mazo oil, nightshade oil) Avoid greasy, sour foods that are tasty and dry. Simple soups, spinach soup, ice cream cheese, plain cabbage soup, fat foods include camel hump, sheep tail, chicken tallow, duck tallow Egg yolks - especially before eating, Mortar of egg yolk, leek and onion cooked with beef oil and not too coagulated, Coconut, almond, do not eat thick meat and milk-based foods, from blood-burning things such as spicesFood flavoring should be avoided, thin and easily digestible meats, cumin broth, pea juice,Dates and figs

 References: 1-Researchgate/The Approach of Traditional Persian Medicine to Treatment of Anal Fissure/2019 2-Researchgate/ Wallflower (Erysimum cheiri(L.) Crantz)from Past to Future/2019